Table 1

Pulmonary function testing results before and after intrathecal baclofen treatment

FVC

FEV1

FEF 25-75%

PEF

TLC

RV

DLCO

Study 1†

Pre-Bronchodilator

1.83 L (44% Ref)

1.60 L (49% Ref)

2.20 L/sec (73% Ref)

5.34 L/sec (71% Ref)

2.71 L (45% Ref)

0.88 L (40% Ref)

12.20 mL/mmHg/min (44% Ref)

Post -Bronchodilator

2.06 L (50% Ref)

1.78 L (54% Ref)

2.44 L/sec (81% Ref)

4.62 L/sec (62% Ref)

NA

NA

NA

Study 2††

Pre-Bronchodialtor

1.95 L (47% Ref)

1.57 L (49% Ref)

1.59 L/sec (53% Ref)

4.74 L/sec (64% Ref)

3.07 L (52% Ref)

1.10 L (50% Ref)

11.00 mL/mmHg/min (36% Ref)

Post -Bronchodilator

2.18 L (53% Ref)

1.79 L (55% Ref)

1.97 L/sec (66% Ref)

4.89 L/sec (66% Ref)

NA

NA

NA

† Patient intrathecal medication dose at time of study: Baclofen 0 μg/day, Dilaudid 26.5 mg/day

†† Patient intrathecal medication dose at time of study: Baclofen 400 μg/day, Dilaudid 21.5 mg/day

Irwin and Schwartzman Journal of Brachial Plexus and Peripheral Nerve Injury 2011 6:6   doi:10.1186/1749-7221-6-6