Figure 7.

Effect of femoral artery I/R induced neuronal histopathological changes shown in figure a to f (sham, ischemia control, vehicle, tacrolimus (1), tacrolimus (2) and tacrolimus (3) respectively). Fig. b shows neuronal edema and degeneration as compared to sham control group. Moreover, fig e and f shows amelioration of tacrolimus (2 and 3 mg/kg) on neuronal edema and degeneration in sciatic nerve of rat. Microscopic examinations were performed under 450 × light microcopy, scale bar 10 μm.